The infectiologists have the floor: An opinionated take on NEJM highlights for March 2020
Marc Herant
March 31, 2020
A first Covid-19 interventional study – unfortunately negative The first of what promises to be a series of many interventional studies for acute Covid-19 disease to appear in the Journal. Lopinavir is an HIV drug that had shown in-vitro activity against SARS, another corona virus, and ritonavir is a drug that boosts lopinavir concentration by reducing its rate of metabolization – so it was worth trying the combo in sick patients with Covid-19. The study was clearly conducted in quasi-battlefield conditions in one of Wuhan’s main hospital from mid-January to