Small but real progress in ALS:
Despite enormous public attention and significant effort, ALS remains a disease for which the development of new therapies has been challenging. Animal models showed po…
OptumCare’s acquisitions usually make headlines. But what happens when the reporters leave? How is clinical capacity managed? What role do micro-acquisitions, recruiting and retirements play in advan…
Summary:
We conducted a comparative analysis of the referral networks of orthopedic surgeons in King County (the area around Seattle, WA) and Miami-Dade County.
Similarities
Bigger systems are better…
PDF: An ADC renaissance: a resurgence of antibody drug conjugates for cancer
Summary:
Antibody-drug conjugates (ADCs) have seen a record number of approvals in 2020. This comes after a first era of i…
A cheap, low tech intervention for a common Achilles’ heel
When I am out and about, for instance at the grocery store, I am always surprised at the number of people I see with swollen legs. About half…
Stunting and the microbiome
Stunting (low growth for age) affects > 20% of children across the globe and has major impact on the brain, on health, and on opportunities for success in life. The prec…
What’s your blood type?
The first report of a genome wide association study of Covid-19 severity on approximately 4000 patients and controls conducted in Spain and Italy identifies a locus on the 3rd…
COVID-19 has accelerated the adoption of AI in healthcare. AI based tools and solutions can work quickly, be deployed at scale, and respond to the dynamic nature of the crisis. Use-cases span all face…
Remdesivir works… but not enough to change the public health perspective
The eagerly awaited results of the remdesivir NIH trial are out, and it’s solid but not smashing, although this is a partial re…
Summary
NaviHealth is a leader in post-acute care management; since it manages but does not provide care, its impact is constrained by quality of available providers
By aligning with Optum clinical a…
Among Covid’s many repercussions, the recession shock will drive a sustained degradation of provider payer mix. I estimate that each 5% added to unemployment will incrementally reduce hospital[1] ope…
Health Affairs has put out another study – this one by Skopec and team (subscription access) - comparing post-acute care (PAC) among Medicare Advantage (MA) vs. traditional Medicare (FFS). And, once a…
Hydroxychloroquine does not seem to help much in Covid-19 (with caveat)
There has been significant attention to the use of the antimalarial hydroxychloroquine in Covid-19, but data on impact has been …
Preamble
A recent post from Recon Strategy outlined the longer-term strategic implications of Covid-19 on 12 healthcare sectors. This post highlights the opportunity to redeploy corporate strategy ass…
Even as our priority today is dealing with the Covid crisis, healthcare organizations would do well to start thinking about the longer-term implications for their strategies. In some instances the mar…
A first Covid-19 interventional study – unfortunately negative
The first of what promises to be a series of many interventional studies for acute Covid-19 disease to appear in the Journal. Lopinavir i…
Keeping up with COVID-19
It’s not easy for a refereed weekly print periodical to keep up with an epidemic that evolves on a daily basis, but the NEJM is doing its best and all articles are free on-lin…
The loneliness of the patent-less drug
Colchicine is a very old drug commonly used in gout with an anti-inflammatory mechanism of action that is not well defined. It is a generic (although in the US, …
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